Functional Relevance of the Stretch-Dependent Slow Force Response in Failing Human Myocardium
نویسندگان
چکیده
منابع مشابه
Functional relevance of the stretch-dependent slow force response in failing human myocardium.
Stretch induces immediate and delayed inotropic effects in mammalian myocardium via distinct mechanosensitive pathways, but these effects are poorly characterized in human cardiac muscle. We tested the effects of stretch on immediate and delayed force response in failing human myocardium. Experiments were performed in muscle strips from 52 failing human hearts (37 degrees C, 1 Hz, bicarbonate b...
متن کاملStretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent.
OBJECTIVE Stretch induces functional and trophic effects in mammalian myocardium via various signal transduction pathways. We tested stretch signal transduction on immediate and slow force response (SFR) in rabbit myocardium. METHODS Experiments were performed in isolated right ventricular muscles from adult rabbit hearts (37 degrees C, 1 Hz stimulation rate, bicarbonate-buffer). Muscles were...
متن کاملReduced Stretch-Induced Force Response in Failing Human Myocardium Caused by Impaired Na -Contraction Coupling
Background—Stretch elicits an immediate, followed by a delayed, inotropic response in various animal models and failing human myocardium. This study aimed to characterize functional differences in the stretch response between failing and nonfailing human myocardium. Methods and Results—Experiments were performed in muscle tissue from 86 failing and 16 nonfailing human hearts. Muscles were stret...
متن کاملReduced stretch-induced force response in failing human myocardium caused by impaired Na(+)-contraction coupling.
BACKGROUND Stretch elicits an immediate, followed by a delayed, inotropic response in various animal models and failing human myocardium. This study aimed to characterize functional differences in the stretch response between failing and nonfailing human myocardium. METHODS AND RESULTS Experiments were performed in muscle tissue from 86 failing and 16 nonfailing human hearts. Muscles were str...
متن کاملAngiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium.
AIMS Stretch is an important regulator of atrial function. The functional effects of stretch on human atrium, however, are poorly understood. Thus, we characterized the stretch-induced force response in human atrium and evaluated the underlying cellular mechanisms. METHODS AND RESULTS Isometric twitch force of human atrial trabeculae (n = 252) was recorded (37 degrees C, 1 Hz stimulation) fol...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000129181.48395.ff